Mood Emot 2020 Nov; 18(3): 83-89   https://doi.org/10.35986/me.2020.18.3.83
Lack of Association between Metabolic Syndrome and Depression in Korean Adults: Analysis Based on the 2016 and 2018 Korean National Health and Nutrition Examination Surveys
Seon Gu Kim, MD1 , Sung Woo Park, PhD2,3,4 , Mi Kyoung Seo, PhD3 , Taekjoong Kim, MD, PhD5 , Jung Goo Lee, MD, PhD1,3,4
1Department of Psychiatry, Haeundae Paik Hospital, College of Medicine, Inje University, 2Department of Convergence Biomedical Science, College of Medicine, Inje University, 3Paik Institute for Clinical Research, Inje University, 4Department of Health Science and Technology, Graduate School, Inje University, 5Department of Humanities and Social Sciences in Medicine, College of Medicine, Inje University, Busan, Korea
Correspondence to: Jung Goo Lee, MD, PhD
Department of Psychiatry, Haeundae Paik Hospital, College of Medicine, Inje University, 875 Haeun-daero, Haeundae-gu, Busan 48108, Korea
TEL +82-51-890-6749 FAX +82-51-894-6709 E-mail iybihwc@naver.com ORCID https://orcid.org/0000-0003-3393-2667
Received: June 25, 2020; Revised: August 11, 2020; Accepted: September 13, 2020; Published online: November 30, 2020.
© Korean Society for Affective Disorders. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: This study aims to investigate the relationship between metabolic syndrome and depression in Korean adults using data from the 2016 and 2018 Korean National Health and Nutrition Examination Surveys (KNHANES).
Methods: The total number of participants in the 7th period 1st year (2016) and 3rd year (2018) surveys of KNHANES was 16142. This study was conducted with 10,722 subjects who met the diagnostic criteria for metabolic syndrome and responded to the Patient Health Questionnaire-9 (PHQ-9). Analysis of covariance was used to adjust the differences due to demographic factors, laboratory findings, and underlying diseases to understand the relationship between metabolic syndrome and PHQ-9 scores, if any.
Results: The prevalence of metabolic syndrome was determined to be 25.6% in this study. The PHQ-9 scores with and without metabolic syndrome were 2.56 and 2.48, respectively, and there was no significant difference when the confounding variable was corrected (p=0.406). According to the analysis of each PHQ-9 item and metabolic syndrome, the results were not significant.
Conclusion: In this cross-sectional study conducted in Korean adults, no significant correlation was found between metabolic syndrome and depression.
Keywords: Depression; Patient Health Questionnaire-9; Metabolic syndrome; Korea

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