Mood Emot 2021 Mar; 19(1): 1-10
Changes Caused by the Melatonergic System in Young Patients with Mood Disorders: A Literature Review
Jung Hyun Lee, MD, PhD1 , Eunsoo Moon, MD, PhD2,3
1Department of Pediatrics, Kosin University College of Medicine, 2Department of Psychiatry, Biomedical Research Institute, Pusan National University Hospital, Busan, 3Department of Psychiatry, Pusan National University School of Medicine, Yangsan, Korea
Correspondence to: Eunsoo Moon, MD, PhD
Department of Psychiatry, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan 49241, Korea
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Received: September 29, 2020; Revised: November 12, 2020; Accepted: November 12, 2020; Published online: March 31, 2021.
© Korean Society for Affective Disorders. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The abnormalities caused by the melatonergic system have been associated with psychiatric disorders, such as Alzheimer’s dementia and schizophrenia, as well as with the pathogenesis of mood disorders. Abnormal melatonin secretion has been observed in the early phase of mood disorders in young patients and high-risk adults. This review summarizes and discusses the findings of studies that have investigated the melatonergic system in children, adolescents, and young adults with mood disorders. Furthermore, the factors associated with the changes caused by the melatonergic system during the early stage of mood disorders are evaluated.
Keywords: Depression; Bipolar disorder; Melatonin; Child; Adolescent

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