Mood Emot 2024 Nov; 22(3): 69-77   https://doi.org/10.35986/me.2024.22.3.69
Cross-Sectional Observation of the Factors for Long-Term Maintenance of Long-Acting Injectable Antipsychotics in Schizophrenia
Hyuk Gwon , MD, Bo-Hyun Yoon , MD, PhD, Kyungmin Kim , MD, Hangoeunbi Kang , MD, Hyunju Yun , MD, Yuran Jeong , MD, Ha-Ran Jung , MD, Jye-Heon Song , MD, Suhee Park , MD, Young-Hwa Sea , MD, Jaegil Jo , MD
Department of Psychiatry, Naju National Hospital, Naju, Korea
Correspondence to: Bo-Hyun Yoon, MD, PhD
Department of Psychiatry, Naju National Hospital, 1328-31 Senam-ro, Sanpo-myeon, Naju 58213, Korea
TEL +82-61-330-4101 FAX +82-61-330-5150 E-mail byoon01@gmail.com ORCID https://orcid.org/0000-0002-3882-7930
Co-Correspondence: Kyungmin Kim, MD
Department of Psychiatry, Naju National Hospital, 1328-31 Senam-ro, Sanpo-myeon, Naju 58213, Korea
TEL +82-61-330-4101 FAX +82-61-330-5150 E-mail heilyooa@gmail.com ORCID https://orcid.org/0000-0001-5376-1418
Received: October 27, 2024; Revised: November 10, 2024; Accepted: November 11, 2024; Published online: November 30, 2024.
© Korean Society for Affective Disorders. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: This study aimed to identify factors that influence the maintenance of long-acting injectable antipsychotics (LAI) for over a year in patients with schizophrenia.
Methods: Seventy patients from Naju National Hospital were divided into two groups: those who maintained LAI for over a year (maintaining group, n=39) and those who discontinued (dropout group, n=31). Sociodemographic and clinical factors were compared using medical records and assessments, including the Birchwood Insight Scale (BIS), Drug Attitude Inventory-10 (DAI-10), and World Health Organization Quality of Life assessment instrument.
Results: The number of rehospitalizations was significantly lower in the maintaining group (p=0.030). The highest previous Global Assessment of Functioning Scale score within a year of starting LAI was significantly higher in the maintaining group (p=0.002), with a higher number of individuals being employed in this group (p=0.029). The mean BIS (p=0.010) and DAI-10 (p=0.003) scores were higher in the maintaining group. Logistic regression analysis revealed that the DAI-10 (B=0.148, p=0.014) had a significant impact on maintaining LAI.
Conclusion: Our study suggests that a positive drug attitude is one of the key factors in maintaining LAI treatment, preventing relapses and supporting long-term stabilization in schizophrenia.
Keywords: Schizophrenia; Antipsychotic agents; Medication adherence

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