Mood Emot 2022 Nov; 20(3): 59-64   https://doi.org/10.35986/me.2022.20.3.59
Influences of Dopamine D2, D3 Agonist Quinpirole Dosage on Locomotor Activity Measured by Open-Field Test
Jeonghyun Park, BS1 , Eunsoo Moon, MD, PhD1,2 , Hyun Ju Lim, MS1,3 , Kyungwon Kim, MD, PhD1 , Jung Hyun Lee, MD, PhD4 , Yoo Rha Hong, MD, PhD4
1Department of Psychiatry and Biomedical Research Institute, Pusan National University Hospital, Busan, 2Department of Psychiatry, Pusan National University School of Medicine, Yangsan, 3Department of Psychology, Gyeongsang National Universtiy, Jinju, 4Department of Pediatrics, Kosin University College of Medicine, Busan, Korea
Correspondence to: Eunsoo Moon, MD, PhD
Department of Psychiatry and Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, 179 Gudeok-ro, Seo-gu, Busan 49241, Korea
TEL +82-51-240-7303 FAX +82-51-248-3648 E-mail esmun@hanmail.net ORCID https://orcid.org/0000-0002-8863-3413
Yoo Rha Hong, MD, PhD
Department of Pediatrics, Kosin University College of Medicine, 262 Gamcheon-ro, Seo-gu, Busan 49267, Korea
TEL +82-51-990-6121 FAX +82-51-990-3071 E-mail pondhong@gmail.com ORCID https://orcid.org/0000-0002-7673-070X
Received: November 10, 2022; Accepted: November 16, 2022; Published online: November 30, 2022.
© Korean Society for Affective Disorders. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Dopamine D2 and D3 receptor agonist quinpirole have been tried as one of drug-induced bipolar animal models. An open-field test is used to assess locomotor activity related to anxiety. Not many studies have analyzed the effects of quinpirole dosages on locomotor activity. The purpose of this study was to look at the locomotor activity of quinpirole-injected mice in an open-field test.
Methods: The open-field test was used to observe the locomotor activities of 28 mice. Quinpirole was administrated at 0.05-5 mg/kg and normal saline were used as a control. The Mann-Whitney U-test was employed to compare the locomotor activities in the quinpirole and control groups.
Results: Quinpirole-induced locomotor activities reduced as time elapsed during the first 30 minutes following the injection in most mice, then increased or fluctuated in the later 30 minutes. As the dosage was increased, there was a stronger initial inhibition, followed by a rapid and further increase in the last 30 minutes.
Conclusion: This study showed the differential effects of quinpirole-induced locomotor activities depending on dosage, and initial suppression of locomotor activities by quinpirole was observed. Additionally, longitudinal observation of more than 1 hour would be required to look into the biphasic pattern of quinpirole in an animal model.
Keywords: Open field test; Locomotion; Quinpirole; Dopamine agonists; Mice

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