Mood Emot 2024 Mar; 22(1): 27-35   https://doi.org/10.35986/me.2024.22.1.27
Effect of Metabolic Syndrome and Metabolic Abnormalities on Remission of Bipolar Disorder Inpatients: A Retrospective Chart Review Study
Suwan Kim, MD1 , Young Sup Woo, MD, PhD2 , Won-Seok Choi, MD, PhD2 , Won-Myong Bahk, MD, PhD2
1St. Mary’s Saebom Psychiatric Clinic, 2Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea
Correspondence to: Young Sup Woo, MD, PhD
Department of Psychiatry, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 10 63-ro, Yeongdeungpo-gu, Seoul 07345, Korea
TEL +82-2-3779-1139 FAX +82-2-761-8497 E-mail youngwoo@catholic.ac.kr ORCID https://orcid.org/0000-0002-0961-838X
Won-Myong Bahk, MD, PhD
Department of Psychiatry, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 10 63-ro, Yeongdeungpo-gu, Seoul 07345, Korea
TEL +82-2-3779-1051 FAX +82-2-761-8497 E-mail wmbahk@catholic.ac.kr ORCID https://orcid.org/0000-0002-0156-2510
Received: October 31, 2023; Accepted: January 10, 2024; Published online: March 31, 2024.
© Korean Society for Affective Disorders. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Associations between metabolic abnormalities and poor treatment outcomes in bipolar disorder (BD) have been reported. This study examined the influence of metabolic abnormalities on remission in Korean inpatients with BD.
Methods: This study retrospectively reviewed the chart of 128 adult patients with BD who were hospitalized at a university hospital in Korea. The collected data included fasting plasma glucose, total cholesterol, triglycerides, and high-density lipoprotein levels at admission, as well as height, weight, and blood pressure measurements. The prevalence of metabolic abnormalities was compared between the remission (17-item Hamilton Depression Rating Scale score of ≤7 and Young Mania Rating Scale score of <8) and nonremission groups.
Results: Prevalence of hyperglycemia and hypertriglyceridemia significantly differed between the nonremission and remission groups. Multivariate analysis revealed hyperglycemia as the only significant risk factor for nonremission in subjects with mood and manic/hypomanic episodes.
Conclusion: The study findings reveal a negative effect of hyperglycemia on the treatment outcome of BD. Clinical attention to metabolic abnormalities, specifically insulin resistance and hyperglycemia, is recommended during early stages of the disease.
Keywords: Bipolar disorder; Remission; Metabolic syndrome; Hyperglycemia


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