Mood Emot 2018 Nov; 16(3): 109-122  
Korean Medication Algorithm for Bipolar Disorder 2018 : Children and Adolescent
Se-Hoon Shim, MD, PhD1, Won-Myong Bahk, MD, PhD2, Bo-Hyun Yoon, MD, PhD3, Duk-In Jon, MD, PhD4, Jeong Seok Seo, MD, PhD5, Won Kim, MD, PhD6, Jung Goo Lee, MD, PhD7, Young Sup Woo, MD, PhD2, Jong-Hyun Jeong, MD, PhD2, Moon-Doo Kim, MD, PhD8, Inki Sohn, MD, PhD9, Hoo-Rim Song, MD, PhD10, and Kyung Joon Min, MD, PhD11
1Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Soonchunhyang University, Cheonan, Korea
2Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea
3Department of Psychiatry, Naju National Hospital, Naju, Korea
4Department of Psychiatry, Sacred Heart Hospital, Hallym University, Anyang, Korea
5Department of Psychiatry, School of Medicine, Konkuk University, Chungju, Korea
6Department of Psychiatry, Seoul Paik Hospital, College of Medicine, Inje University, Seoul, Korea
7Department of Psychiatry, Haeundae Paik Hospital, College of Medicine, Inje University and Paik Institute for Clinical Research and Department of Health Science and Technology, Graduate School of Inje University, Busan, Korea
8Department of Psychiatry, Jeju National University Hospital, Jeju, Korea
9Department of Psychiatry, Keyo Hospital, Keyo Medical Foundation, Uiwang, Korea
10Department of Psychiatry, Myongji Hospital, Goyang, Korea
11Department of Psychiatry, College of Medicine, Chung-Ang University, Seoul, Korea
Correspondence to: 박원명, 07345 서울 영등포구 63로 10(여의도동) 가톨릭대학교 의과대학 여의도성모병원 정신건강의학과 전화 : (02) 3779-1051·전송 : (02) 780-6577·E-mail : wmbahk@catholic.ac.kr
민경준, 06973 서울 동작구 흑석로 102 중앙대학교 의과대학 정신건강의학교실 전화 : (02) 6299-1521·전송 : (02) 6298-1508·E-mail : kjoonmin@gmail.com
Received: October 5, 2018; Revised: October 9, 2018; Accepted: October 14, 2018; Published online: November 30, 2018.
© Korean Society for Affective Disorders. All rights reserved.

Abstract
Objectives : The objective of this study was to revise the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) 2014: Children and Adolescents.
Methods : We performed the survey, using a questionnaire comprising 22 questions according to each situation, in children and adolescents with bipolar disorder.
Results : First-line pharmacotherapeutic strategies for manic episode in children with bipolar disorder were a combination of mood stabilizer (MS) and an atypical antipsychotics (AAP), monotherapy with an AAP, risperidone, and aripiprazole. Aripiprazole was selected as first-line medication for depressive episode in children with bipolar disorder, and aripiprazole, and risperidone were selected as first-line at high-risk children. First-line pharmacotherapeutic strategies for manic episode in adolescents were a combination of MS and an AAP, monotherapy with an AAP valproate, lithium, risperidone (Treatment of Choice, TOC), aripiprazole, and quetiapine. First-line pharmacotherapeutic strategies for depressive episode in adolescents, were a combination of an atypical antipsychotics and lamotrigine, valproate, aripiprazole (TOC), risperidone, and quetiapine. For depressive episodes in adolescents at high risk for bipolar disorder, valproate, aripiprazole (TOC), and risperidone were selected as first-line medication.
Conclusion : We expect that the present KMAP-BP 2018-children and adolescents, is useful for clinicians to treat children and adolescents with bipolar disorder.
Keywords: Bipolar disorder ㆍChildren and adolescents ㆍPharmacotherapy ㆍKMAP-BP 2018.

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